FORT COLLINS – Science and technology startup incubator Innosphere announced on Thursday that it has admitted its largest group to date, with 12 new client companies joining the program.

All but one of those startups are based in Northern Colorado or the Boulder Valley.

Fort Collins-based Innosphere is a nonprofit organization that works with startups for two years, helping them with things like launching their companies, crafting business models, building teams and raising capital. The organization operates out of three locations in Fort Collins, as well as the National Renewable Energy Laboratory in Golden. A Denver location opened in June.

Innosphere admits new client companies three times per year. The new group included a specific focus on startups looking to commercialize technology to improve efficiency and reduce environmental impacts in the oil and gas industry, with four of the 12 companies fitting that mold.

The 12 new Innosphere companies include:

Cool Energy Inc.: The Boulder company makes a ThermoHeart Engine that converts low-temperature waste heat into clean electricity.

PetroDe: The Broomfield company aggregates and analyzes data on U.S. wells and production and provides companies with visual reports with its graphical mapping system.

Sustainable Power Systems: The Boulder company’s technology aims to reduce the cost and environmental impact of energy production in remote locations by combining renewable and conventional energy along with storage and load management.

Vortex Tools: The Littleton company has developed multiple patented tools to help extend the life, efficiency and productivity of oil and gas wells.

Agribotix: The Boulder-based ag-tech company has a drone-fueled data analysis platform that helps farmers analyze data on their fields and decide where to focus fertilization or watering efforts.

Growcentia: The Fort Collins company makes organic soil supplements that naturally increase nutrient availability to support healthy plants, reducing the need for chemical inputs.

AllProWebTools: The Fort Collins company’s software platform helps businesses manage marketing, sales and other core functions with one solution.

Black Square Technologies: The Boulder company makes a USB-compatible device that allows users to easily encrypt files stored on their computers and in the cloud or that they send in emails.

Green Sun Medical: The Fort Collins company is developing treatments to address Adolescent Idiopathic Scoliosis.

Telespine: The Boulder company provides an online 8-week program that helps alleviate lower back pain.

Leo Technologies: The Boulder company has developed a wireless sensor that helps people monitor their hydration level in real time.

Peak Efficiency: The Windsor company develops and implements utility-scale alternative energy products.