Heart stent reduces risk of complications
![Dr. Nelson Trujillo, a cardiologist at Boulder Community Health, is the first in the area to begin using the Synergy stent. The device is pre-medicated, which reduces scarring and incidents of re-stenting.](https://bizwest.com/wp-content/uploads/2022/04/stent_2-scaled.jpg.optimal.jpg)
Until just a few months ago, more than half of the patients with heart disease who had arterial stents installed to maintain the flow of blood during an angioplasty procedure could expect complications such as blood clots, which could lead to a heart attack and even death — the very reason they were in the doctor’s care in the first place.
It’s a grim merry-go-round heart patients don’t have to ride any more thanks to a new treatment offered by Boulder Community Health, the only hospital along the Front Range that offers this treatment. Developed by Boston Scientific Corp., the Synergy stent treatment combines old stent technology with a way of limiting the amount of time that scar-tissue medication stays in the system. Boston Scientific provides medical solutions for patients with conditions that range from heart problems to issues with chronic pain.
Dr. Nelson Trujillo, a cardiologist at Boulder Community Health, said the Synergy stent is a “new generation of stent. A lot of problems with stents are related to how they heal. With the technology on this new device, it really improves the heart’s ability to heal. It will lead to people needing less medication in the long term with a better result. I’m pleased and proud for being the first to put these in for our community.”
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Stents are tiny mesh tubes that doctors use to keep clogged arteries open, allowing blood to flow freely to the heart. They are designed to stay permanently in the patient’s body.
![The SYNERGY stent. © 2015 Boston Scientific Corporation or its affiliates. All rights reserved. Used with permission by Boston Scientific Corporation](https://bizwest.com/wp-content/uploads/2022/04/stent-3.jpg.optimal.jpg)
© 2015 Boston Scientific Corporation or its affiliates. All rights reserved. Used with permission by Boston Scientific Corporation
Using a stent to keep a plaque-hardened artery open is not new; they have been used for more than a decade in patients with heart disease, but they fail in two ways: through scarring and blood-clot formation, Trujillo said.
The typical stent, made of platinum chromium, can be used with or without medication, depending on the patient’s needs. In the first generation of stents, scar tissue sometimes would grow over the stent. In the next big innovation with stents, medication was added to prevent scar tissue and resulting re-narrowing. The medication delivered, Everolimus, is related to chemotherapy agents and comes from Pacific yew trees. Everolimus is added to a polymer, and the stent is coated with it “so that there are parts of the artery that get exposed to the polymer that don’t need to be,” Trujillo said.
While this system works, it slows down healing inside the artery and increases blood-clot risk. Patients are exposed to blood-thinning medications for long periods in order to prevent development of blood clots that can lead to heart attacks. But taking blood thinners is tricky; too big of a dose can cause major bleeding, while not enough means blood clots can still form.
The new stent solves that problem. “With the Synergy stent, the polymer and the medication (it’s the same medication, Everolimus), are limited to the outside stent structure so it’s opposed to the blood vessel, so it is applied in a limited way just in the places it needs to be,” Trujillo said. “That limits the amount of inflammation that occurs, letting the vessel heal faster and more efficiently,”
He added that the Synergy stent is different in the way the scar tissue preventing medication, which is attached to the stent, is delivered. Older-generation stents do have medicine that aids in scar-tissue prevention, but the medicine stays in the body for a long, undeterminable amount of time. This slows healing inside the artery. Trujillo said getting ahead of scar-tissue formation is especially important in the tiny blood vessels of the heart. Most stents are 2 to 4 millimeters wide to fit the arteries into which they are designed to go. As a comparison, the tip of a ballpoint pen, which is roughly 4 millimeters, would be a large artery. Scarring can cause blockages.
Scarring does not always happen, Trujillo said, but the new stent makes it much less likely. “We measure scarring based on what we see on an angiogram, what shows up in the clinics, and who needs to be re-stented,” he said. Bare-metal stents saw scarring at a rate of 15 percent. With a medication coating, that falls to 6 percent.
“The chances of scarring with the new stent are 2 percent,” Trujillo said. He compared this new way of delivering medication to time-released medications.
Although the stent was developed in the United States, it jas been available in European markets for two years. In 2010, there were 454,000 insertions of a coronary-artery stent, according to the federal Centers for Disease Control and Prevention. Prior to this year, Trujillo calculated, he has installed 100 to 200 stents a year.
Until just a few months ago, more than half of the patients with heart disease who had arterial stents installed to maintain the flow of blood during an angioplasty procedure could expect complications such as blood clots, which could lead to a heart attack and even death — the very reason they were in the doctor’s care in the first place.
It’s a grim merry-go-round heart patients don’t have to ride any more thanks to a new treatment offered by Boulder Community Health, the only hospital along the Front Range that offers this treatment. Developed by…
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